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HMG499
CAS No. 2416941-68-7
HMG499 ( —— )
Catalog No. M21875 CAS No. 2416941-68-7
HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC50 of 0.41 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1229 | Get Quote |
|
| 50MG | 2507 | Get Quote |
|
| 100MG | 3168 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameHMG499
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NoteResearch use only, not for human use.
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Brief DescriptionHMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC50 of 0.41 μM.
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DescriptionHMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC50 of 0.41 μM. HMG499 can prevent statins-induced accumulation of HMGCR, reduce serum cholesterol levels and decrease atherosclerosis.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetHMGCR
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RecptorIC50: 0.41 μM (HMG-CoA reductase)
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Research Area——
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Indication——
Chemical Information
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CAS Number2416941-68-7
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Formula Weight498.78
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Molecular FormulaC??H??O?
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Purity>98% (HPLC)
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Solubility——
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SMILESC[C@H](CCCC(CC=C)(CC=C)O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C=C4C(C)(C)[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jiang SY, et al. Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol. Nat Commun. 2018 Dec 3;9(1):5138.
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